THE EFFECT OF BETA BLOCKERS ON THE CLINICAL COURSE AND HEMODYNAMICS IN PATIENTS WITH DILATED CARDIOMYOPATHIES`

Bakamov Dilshod

doi:10.17605/OSF.IO/672CU

Authors

Bakamov Dilshod Republican Scientific Center of Emergency Hospital, Bukhara branch

DOI:

https://doi.org/10.17605/OSF.IO/672CU

Keywords:

Dilated cardiomyopathy (DCM),beta blockers,angiotensin-converting enzyme,Carvedilol

Abstract

Dilated cardiomyopathy (DCM) is the most common (60% of all cardiomyopathies) and occurs in all countries of the world with a frequency of 5 - 8 cases per 100,000 population, in particular, 36 cases per 100,000 population are registered in the USA. DCM is a myocardial disease characterized by dilatation of the heart chambers, impaired contractile function, and progressive chronic heart failure (CHF). The criterion for disease is a decrease in the left ventricular ejection fraction below 45% and an increase in the size of the left ventricular (LV) cavity in diastole more than 6 cm (2013 ACCF / AHA Guideline for the Management of Heart Failure

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References

Matsumori A, Wang H, Abelmann WH, Crumpacker CS: Treatment of viral myocarditis with ribavirin in an animal preparation. Circulation 1985;71:834-839

Costanzo-Nordin MR, Areap E, O'Connell JB, Robinson JA, Scanlon PJ: A nonsteroidal antiinflammatory drug exacerbates coxsackievirus B3 murine myocarditis. J Am Coll Cardiol 1985;6:1078-1082

Connell JB, Reap EA, Robinson JA: The effects of cyclosporine on acute murine coxsackie B3 myocarditis. Circulation 1986;73:353-359

Tomioka N, Kishimoto C, Matsumori A, Kawai C: Effect of prednisolone on acute viral myocarditis in mice. J Am Coll Cardiol 1986;7:868-872

Rezkalla S, Khatib G, Khatib R: Coxsackievirus B3 murine myocarditis: Deleterious effects of nonsteroidal antiinflammatory agents. J Lab Clin Med 1986;107:393-395

Matsumori A, Crumpacker CS, Abelmann WH: Prevention of viral myocarditis with recombinant human leukocyte interferon alpha A/D in a murine model. J Am Coll Cardiol 1987;9:1320-1325

Rezkalla S, Kloner RA, Khatib G, Khatib R: Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis. Circulation 1990;81:1039-1047

Anderson JL, Carlquist JF, Hammond EH: Deficient natural killer cell activity in patients with idiopathic dilated cardiomyopathy. Lancet 1982;2:1124-1127

Waagstein F, Hjalmarson A, Varnauskas E, Wallentin I: Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy. Br Heart J 1975;37:1022-1036

Swedberg K, Hjalmarson A, Waagstein F, Wallentin I: Beneficial effect of long-term beta-blockade in congestive cardiomyopathy. Br Heart J 1980;44:117-133

Swedberg K, Hjalmarson A, Waagstein F, Wallentin I: Adverse effect of beta-blockade withdrawal in patients with congestive cardiomyopathy. Br Heart J 1980;44:134-142

Waagstein F, Caidahl K, Wallentin I, Bergh CH, Hjalmarson A: Long-term ,3-blockade in dilated cardiomyopathy: Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol. Circulation 1989;80:551-563

Anderson JL, Lutz JR, Gilbert EM, Sorensen SG, Yanowitz FG, Menlove RL, Bartholomew M: A randomized trial of low-dose beta-blockade therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1985;55:471-475

Engelmeier RS, O'Connell JB, Walsh R, Rad N, Scanlon PJ, Gunnar RM: Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: A double-blind, randomized, placebo-controlled trial. Circulation 1985;72:536-545

Gilbert EM, Anderson JL, Deitchman D, Yanowitz FG, O'Connell JB, Renlund DG, Bartholomew M, Mealey PC, Larrabee P, Bristow MR: Long-term 13-blocker vasodilation therapy improves cardiac function in idiopathic dilated cardiomyopathy: A double-blind, randomized study of bucindolol versus placebo. Am J Med 1990;88:223-229

Swedberg K, Hjalmarson A, Waagstein F, Wallentin I: Prolongation of survival in congestive cardiomyopathy by betareceptor blockade. Lancet 1979;1:1374-1379

Kawai C, Matsumori A, Kitaura Y, Takatsu T: Viruses and the heart: Viral myocarditis and cardiomyopathy. Prog Cardiol 1978;7:141-162

Kawai C, Matsumori A, Fujiwara H: Myocarditis and dilated cardiomyopathy. Annu Rev Med 1987;38:221-239

Rezkalla S, Kloner RA, Khatib G, Smith F, Khatib R: Effect of metoprolol in acute coxsackievirus B3 murine myocarditis. J Am Coll Cardiol 1988;12:412-414

Binkley PH, Lewe RF, Lima JJ, Al-Awwa A, Unverferth DV, Leier CV: Hemodynamic-inotropic response to 13-blocker with intrinsic sympathomimetic activity in patients with congestive cardiomyopathy. Circulation 1986;74:1390-1398