CYTOKINE STATUS IN HIV INFECTED WOMEN WITH INFLAMMATORY DISEASES OF THE GENITALS
##plugins.themes.academic_pro.article.sidebar##
Downloads
##plugins.themes.academic_pro.article.main##
Abstract
The aim of the study was to study the cytokine profile in HIV-infected women with acute vaginitis during treatment Materials and methods- the study examined 35 women for 2019-2020 with HIV infection and 20 women who were conditionally healthy, a control group. The level of cytokines (IFNγ, IL-17) in the serum of peripheral blood was studied by enzyme-linked immunosorbent assay using test systems "Vector-Best" Results and discussion: the ratio of IFNγ / IL-17 (pro-inflammatory / anti-inflammatory cytokines or Tx1 / Tx2) in healthy women was 2.2. In the presence of a pronounced inflammatory process, that is, in women of the main group, this indicator was 0.96. After immunocorrecting treatment with the use of Imunorix in women with nonspecific vaginitis, IFNγ approached the control values, the content of IL-17, and after treatment did not normalize, remaining 5.5 times higher than in women of the control group, the ratio of IFNγ / IL-17. in women of the main group, after treatment, this indicator decreased to 0.42. Conclusion: A violation of the ratio of pro- and anti-inflammatory cytokines to talk about the presence of a previous immunodeficiency state and was manifested by the presence of complications in the presence of acute vaginitis.
##plugins.themes.academic_pro.article.details##
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
- Bugubaeva MM, Kadyrova RM Clinical and epidemiological characteristics of children with perinatal contact for HIV infection // Reference book of a general practitioner. - 2015. - No. 3. - S. 54-58.
- Burkhanov RA, Mamanov MM Phenotypic risk factors for HIV infection and the development of Acquired Immunodeficiency Syndrome // News of Dermatology and Venereology .- (Central Asian Scientific and Practical Journal). - 2019. - No. 3. - S. 39-41.
- Varpakhovskaya IM Acquired Immunodeficiency Syndrome: immunomodulators, vaccines, new methods of treatment // Remedium. - Moscow, 2015. - No. 1. - S. 64-68.
- Kubanova AA, Akovbyan VA, Toskin IA Modern concepts of the epidemiological process of sexually transmitted infections and HIV infection // Bulletin of Dermatology and Venereology. - 2016. - No. 6. - S. 1-4.
- Kulakov V.I., Baranov I.I. HIV: prevention of mother-to-child transmission. - M., 2017. –S. twenty.
- Merkushkina TA, Mirakhmedova NN, The concentration of cytokines IFN-gamma and IL-4 in HIV / AIDS disease in children and adults // Journal of Theoretical and Clinical Medicine. - Tashkent, 2017.- C.163.
- Moskaleva EV Dynamics of immune status indicators against the background of antiretroviral therapy correction in children with perinatal HIV infection // Days of immunology in Siberia: mater. vseros. scientific-practical conf., dedicated. 30th anniversary of the GUNII honey. problems of the North of the SB RAMS and the 25th anniversary of the GU Research Institute of Clinical Immunology of the SB RAMS. - Krasnoyarsk, 2016 .-- S. 140-141.
- Moskaleva EV Changes in interleukin status indicators in children with perinatal HIV infection against the background of immunocorrection // Questions of modern pediatrics. - 2016. - No. 1. - P. 392-393.
- Narzullaev N.U. FarGALS efficiency in complex treatment of HIV-infected children with acute purulent sinusitis // European Science Review. - Austria, 2017 .-- No.1-2. -pp. 86-88.
- Narzullaev N.U. The Incidence of exudative otitis media in HIV-infected children // International Journal BIOMEDICINE (IJBM) USA. - 2012. -No.1. -pp.211-213.
- Narzullaev N.U. Immune Status of HIV-positive Children with Acute Rhinosinusitis // International Journal of Public Health Science (IJPHS) USA. - 2020. - Vol. 2, No.3. - pp. 83-88.
- N. A. Nuraliev, G. A. Ikhtiyarova, N. I. Olimova, F. Sh. Oripova. Diagnostic Value Determination of Antibodies to Antigensof Micro-Organisms in Women with Inflammatory Diseases of the Pelvic Organs. American Journal of Medicine and Medical Sciences 2020, 10 (2): 124-126