SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1,2,3-TRIAZOLES BASED ON ACETELENE-CONTAINING CARBAMATE DERIVATIVES

Yakubkhodzhaeva M. R; Dzhuraev A. D

doi:10.17605/OSF.IO/Y7RC3

Authors

Yakubkhodzhaeva M. R Tashkent State Dental Institute Tashkent city
Dzhuraev A. D Tashkent State Dental Institute Tashkent city

DOI:

https://doi.org/10.17605/OSF.IO/Y7RC3

Keywords:

carbamates, propargyl ethers, copper acetylenides, silver acetylenides, ɣ-iodopropargyl ethers, anti-inflammatory activity, toxicity

Abstract

In this article, based on propargyl ethers, copper and silver acetylenides of propargyl ethers of carbamate derivatives were synthesized, and on their basis ɣ-iodopropargyl ethers of carbamates were synthesized. By studying the influence of various factors, the optimal conditions for their synthesis have been established. The pharmacological activity and toxicity of the synthesized compounds were studied. Compounds with high anti-inflammatory activity have been identified.

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